NiGHTS Archie Comics
Madame Puffilla only appears in the first Issue of the series. Claris was practicing her singing at her school and her song attracted Elliot, who climbed the wall and started observing her through a window. Claris notices him and got distracted, making Madame Puffilla really angry.
Later that night, Claris is having nightmares where Madame Puffila appears in her dream and transforms into Puffy. NiGHTS arrives to help Claris after hearing her cry for help and together, they defeat Puffy.